Little Known Facts About cees dekker.
Little Known Facts About cees dekker.
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‘Of course, that's about suitable. I hunt for a Actual physical knowledge of Organic units in the bottom-up way. I feel you may distinguish 3 strains of study in my team in the mean time. The 1st issues chromosome construction: How does one get a metre-extended DNA polymer folded and organised in this type of microscopic mobile? We have created visualisation tactics that allow for us to check how, one example is, SMC proteins loop DNA (online video on Youtube) to be able to Construct up chromosomes.
Our group experiments bacterial mobile division and is also aiming to constitute a ‘base up biology’ in artificial cells that will autonomously divide. Our primary interest lies in mobile division, chromatin framework, and spatial Handle.
[Laughs] ‘It was definitely an excellent risk! At the time, I had been perfectly informed that it could go Completely wrong Which I could turn into a lot less effective, but I just ignored that. Curiosity has always been my strongest driving drive. And by chance all of it worked out.’
Nanofabrication of electrodes with sub-5 nm spacing for transport experiments on solitary molecules and metallic clusters
That may be a aspiration of mine and we established to operate using a mouth watering dose of naivety. This really is something which will most likely yield stunning brings about the for a longer time expression, but that doesn't make a difference. You shouldn't only want to operate on the queries of tomorrow, but will also on the inquiries with the working day after tomorrow.’
Our research ranges from the biophysics of DNA to synthetic cells and beyond. Please take a look down below within the spectrum of our present-day jobs.
Many associated developments followed, in which our group set up diverse transistor variants for example solitary-electron transistors at place temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled many transistors into compact evidence-of-theory Digital circuits.
Dynamic ParB–DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation
Imagine if, in place of making use of conventional prime-down silicon electronics, transistors might be crafted from the bottom up using solitary natural and organic molecules since the switching elements? This concept, which turned The idea of now’s discipline of molecular electronics, first emerged while in the 1970s.
Resolving the stage dimension in condensin-driven DNA loop extrusion identifies ATP binding since the phase-creating method
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division
Cees Dekker is Distinguished University Professor at TU Delft. Educated as being a physicist, he pioneered nanotechnology with several discoveries on carbon nanotubes inside the nineties. Due to the fact 2000, he moved to solitary-molecule biophysics and nanobiology. His recent investigation focuses on (i) nanopores for protein sequencing; (ii) chromosome construction, in particular SMC motor protein; and (iii) developing a dwelling artificial cell from lifeless molecules. Dekker is definitely an elected member from the KNAW and fellow towards the APS and also the IOP.
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It was an incredibly interesting time, in the course of which I been given lots of assist from Delft College of Technology, in which I used to be a professor at some time, And that i began many collaborations with molecular ceesdekker biologists. That aided me learn a great deal.’