A Secret Weapon For https://www.ceesdekker.net
A Secret Weapon For https://www.ceesdekker.net
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2009, discovery of a new phenotype for microorganisms in slim nanofluidic slits; and initially detection of neighborhood protein constructions alongside DNA employing stable-state nanopores
Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular types with recombination purpose.
[Laughs] ‘It had been definitely an incredible danger! At time, I was nicely aware that it could go Incorrect and that I could become a lot less prosperous, but I just overlooked that. Curiosity has often been my strongest driving drive. And fortunately it all worked out.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. Within only some months, we had been able to evaluate transportation by way of an individual solitary-walled carbon nanotube. Based on very low-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft University of Technology using an Lively analysis lab at AMOLF in Amsterdam), we showed that carbon nanotubes have been legitimate quantum wires with really extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
What distinguishes biology from chemistry is that these parts with each other make up a dwelling method. The secret of mentioned life, I believe, lies during the interactions, the interplay of those molecules. The large question with regards to the origin of lifestyle remains unanswered. How did we ever evolve from basic molecules into your incredibly elaborate techniques we see currently? We have no idea. I would like to operate on These types of huge, open up concerns.’
Nanopores depict a chic and adaptable Device to measure solitary molecules. We analysis novel detection modes with sound-condition nanopores along with different approaches to measure proteins with nanopores. Tasks encompass the following:
Let's say, rather than working with traditional leading-down silicon electronics, transistors can be created from the bottom up employing single organic and natural molecules as the switching aspects? This idea, which grew to become The premise of right now’s industry of molecular electronics, very first emerged during the seventies.
Resolving the step size in condensin-driven DNA loop extrusion identifies ATP binding as the step-generating process
FtsZ treadmilling is important for Z-ring condensation and septal https://www.ceesdekker.net constriction initiation in bacterial mobile division
Later on we spoke all over again briefly simply because Dekker felt that our discussion of his religion promptly became purely philosophical, whereas Furthermore, it concretely can help him in his work.
Let’s very first seem back again at this time when you decided to shift your target from superconductivity and nanotubes to biology at the end of the nineties.
Supercoiling-dependent DNA binding: quantitative modeling and apps to bulk and single-molecule experiments